Pomsoong C.Mahidol University2023-06-182023-06-182022-01-01Clinical, Cosmetic and Investigational Dermatology Vol.15 (2022) , 1759-1765https://repository.li.mahidol.ac.th/handle/20.500.14594/86296Pityriasis lichenoides et varioliformis acuta (PLEVA) and lymphomatoid papulosis (LyP) are uncommon inflammatory skin disorders that occasionally share clinicopathological features. Differentiating between the two entities remains problematic, and a definitive diagnosis usually requires multi-step investigations, which is an enormous challenge to physicians. We hereby report a rare case of a 22-year-old female patient diagnosed with PLEVA who later developed LyP type F, a new histological variant of LyP. Our report highlights that long-term follow-up is essential to determine associated hematologic malignancies, particularly in cases with recalcitrant or progressive cutaneous lesions of PLEVA and/or LyP.MedicineArticleSCOPUS10.2147/CCID.S3795772-s2.0-8513703657911787015