Visith ThongboonkerdMahidol University2018-10-192018-10-192013-03-01Clinical Science. Vol.124, No.6 (2013), 389-390014352212-s2.0-84872246824https://repository.li.mahidol.ac.th/handle/20.500.14594/32449Abnormalities in clinical parameters and routine laboratory tests are frequently detected at late stages of many diseases (too late to cure or to prevent life-threatening complications). Hence earlier diagnostic and prognostic markers are needed for decision making and improving therapeutic outcome. In the present issue of Clinical Science, Rudiger and co-workers report findings from a transcriptomic study, which revealed that changes in transcripts involved in amino-sugar metabolism, p53-dependent cell-cycle arrest, β-adrenergic signalling and intracellular calcium cycling in cardiac tissue of rats with early sepsis could discriminate survivors from non-survivors. These findings underscore the great potential of systems biology in translational medicine. However, further investigations should be done to make the benchside results more feasible for routine clinical practice. © The Authors Journal compilation.Mahidol UniversityMedicineNoteSCOPUS10.1042/CS20120565