Anawin SanguankeoMariana LazoSikarin UpalaFrederick L. BrancatiSusanne BonekampHenry J. PownallAshok BalasubramanyamJeanne M. ClarkMahidol UniversityColumbia University, College of Physicians and SurgeonsJohns Hopkins Bloomberg School of Public HealthJohns Hopkins UniversityThe Welch Center for Prevention, Epidemiology, Prevention and Clinical ResearchThe Johns Hopkins School of MedicineWeill Cornell Medical CollegeBaylor College of Medicine2018-12-212019-03-142018-12-212019-03-142017-04-03Endocrine Research. Vol.42, No.2 (2017), 86-9515324206074358002-s2.0-84976388643https://repository.li.mahidol.ac.th/handle/20.500.14594/41895© 2017 Taylor & Francis. Objectives: To determine if the reduction of visceral adipose tissue (VAT) volume by lifestyle intervention improved risk factors for cardiovascular disease (CVD) independent of weight loss amount. Design: Ancillary study of randomized-controlled trial. Setting: Data analysis using multivariable regression models. Participants: Participants of the Look AHEAD (Action for HEAlth in Diabetes) Fatty Liver Ancillary Study. Main outcome measures: Correlations between changes in VAT and in CVD risk factors, while adjusting for weight loss and treatment (intensive lifestyle intervention [ILI] vs. diabetes support and education [DSE]). Results: Of 100 participants analyzed, 52% were women, and 36% were black, with a mean age of 61.1 years. In the DSE group, mean weight and VAT changed by 0.1 % (p=0.90) and 4.3% (p=0.39), respectively. In the ILI group, mean weight and VAT decreased by 8.0% (p<0.001) and 7.7% (p=0.01), respectively. Across both groups, mean weight decreased by 3.6% (p<0.001), and mean VAT decreased by 1.2% (p=0.22); the decrease in VAT was correlated with the increase in HDL-cholesterol (HDL-C; R=−0.37; p=0.03). There were no correlations between changes in VAT and blood pressure, triglycerides, LDL-C, glucose, or HbA1c. After adjusting for age, race, gender, baseline metabolic values, fitness, and treatment group, changes in HDL-C were not associated with changes in VAT, while weight changes were independently associated with decrease in glucose, HbA1c, and increase in HDL-C. Conclusions: VAT reduction was not correlated with improvements of CVD risk factors in a sample of overweight and obese adults with type 2 diabetes after adjusting for weight loss.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1080/07435800.2016.1194856