Prapairat SeephonkaiMasahiko IsakaPrasat KittakoopUraiwan BoonudomlapYodhathai ThebtaranothMahidol UniversityThailand National Center for Genetic Engineering and Biotechnology2018-07-242018-07-242004-01-01Journal of Antibiotics. Vol.57, No.1 (2004), 10-16002188202-s2.0-1142275141https://repository.li.mahidol.ac.th/handle/20.500.14594/21812Vertihemipterin A, the ascochlorin glycoside, and its aglycone, 4′,5′-dihydro-4′-hydroxyascochlorin, were isolated from the insect pathogenic fungus Verticillium hemipterigenum BCC 2370. A new analog, 8′-hydroxyascochlorin, and five known compounds, ascochlorin, LL-Z1272ζ, 8′,9′-dehydroascochlorin, ascofuranone and ascofuranol, were also isolated from the same fermentation broth. Structures of these compounds were elucidated by spectroscopic methods. Stereochemistry of the known compound, 4′,5′-dihydro,4′-hydroxyascochlorin, was addressed by NMR spectral analyses and the modified Mosher's method. Antiviral (HSV-1 and cytotoxic activities of these ascochlorin analogs were evaluated.Mahidol UniversityPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.7164/antibiotics.57.10