Chanikan AnuwatgasemTantawan AwirutworakulSakda Arj-Ong VallibhakaraPorntip Kaisa-ArdThidarat YamnimKamonwan PhadermpholPissamai PranudtaPattara WisajunSudawan JullagateFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversityMahidol University2020-10-052020-10-052020-09-01Journal of the Medical Association of Thailand. Vol.103, No.9 (2020), 856-863012522082-s2.0-85091442629https://repository.li.mahidol.ac.th/handle/20.500.14594/59166© JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND 2020 Objective: To find the influences of mindfulness and self-compassion-based group therapy and compare them with standard treatment outcomes. Materials and Methods: Prospective randomized control trial was conducted on two intervention groups (n=23 for mindfulness and self-compassion group, n=11 for the control group) for seven weeks. Depression-related parameters consisted of the Montgomery-Åsberg Depression Rating Scale (MADRS) Thai version, Self-Compassion scale-Thai version (Thai-SCS), Pittsburgh Sleep Quality Index-Thai version (Thai-PSQI), Hospital Anxiety and Depression Scale-Thai version (Thai-HADS), Thai-Perceived Stress Scale-10 (T-PSS-10), Rosenberg self-esteem Thai version, and the World Health Organization Quality of Life (WHOQOL) Thai version, were collected and compared before and after both treatments. Results: Mindfulness and self-compassion had statistically significant improvement of better depressive rating scale, anxiety, mindfulness & self-compassion, perceived stress scale, self-esteem, and quality of life (p<0.001, 0.001, 0.002, <0.001, 0.005 and <0.001, respectively). Depressive level, anxiety level, mindfulness, and self-compassion, perceived stress scale, self-esteem, and quality of life in both groups were also improved. Nonetheless, there were no significant differences when compared to the mean differences between both groups. Conclusion: Mindfulness and self-compassion intervention improved depression, anxiety, stress, self-esteem, and quality of life.Mahidol UniversityMedicineThe effects of mindfulness and self-compassion-based group therapy for major depressive disorder: A randomized controlled trialArticleSCOPUS10.35755/jmedassocthai.2020.09.12020