Chang LiuHelen M. GinnWanwisa DejnirattisaiPiyada SupasaBeibei WangAekkachai TuekprakhonRungtiwa NutalaiDaming ZhouAlexander J. MentzerYuguang ZhaoHelen M.E. DuyvesteynCésar López-CamachoJose Slon-CamposThomas S. WalterDonal SkellySile Ann JohnsonThomas G. RitterChris MasonSue Ann Costa ClemensFelipe Gomes NavecaValdinete NascimentoFernanda NascimentoCristiano Fernandes da CostaPaola Cristina ResendeAlex Pauvolid-CorreaMarilda M. SiqueiraChristina DoldNigel TempertonTao DongAndrew J. PollardJulian C. KnightDerrick CrookTeresa LambeElizabeth ClutterbuckSagida BibiAmy FlaxmanMustapha BittayeSandra Belij-RammerstorferSarah C. GilbertTariq MalikMiles W. CarrollPaul KlenermanEleanor BarnesSusanna J. DunachieVicky BaillieNatali SerafinZanele DitseKelly Da SilvaNeil G. PatersonMark A. WilliamsDavid R. HallShabir MadhiMarta C. NunesPhilip GoulderElizabeth E. FryJuthathip MongkolsapayaJingshan RenDavid I. StuartGavin R. ScreatonSiriraj HospitalMahidol Oxford Tropical Medicine Research UnitNIHR Oxford Biomedical Research CentreOxford University Hospitals NHS Foundation TrustTexas A&M College of Veterinary Medicine & Biomedical SciencesPublic Health EnglandDiamond Light SourceUniversity of the Witwatersrand Faculty of Health SciencesUniversity of OxfordFundacao Oswaldo CruzFiocruz AmazôniaSchool of PathologyUniversity of KentNuffield Department of MedicineUniversità degli Studi di SienaUniversity of Oxford Medical Sciences DivisionOxford HouseFundação de Vigilância em Saúde do Amazonas2022-08-042022-08-042021-08-05Cell. Vol.184, No.16 (2021), 4220-4236.e1310974172009286742-s2.0-85109642517https://repository.li.mahidol.ac.th/handle/20.500.14594/76068Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has undergone progressive change, with variants conferring advantage rapidly becoming dominant lineages, e.g., B.1.617. With apparent increased transmissibility, variant B.1.617.2 has contributed to the current wave of infection ravaging the Indian subcontinent and has been designated a variant of concern in the United Kingdom. Here we study the ability of monoclonal antibodies and convalescent and vaccine sera to neutralize B.1.617.1 and B.1.617.2, complement this with structural analyses of Fab/receptor binding domain (RBD) complexes, and map the antigenic space of current variants. Neutralization of both viruses is reduced compared with ancestral Wuhan-related strains, but there is no evidence of widespread antibody escape as seen with B.1.351. However, B.1.351 and P.1 sera showed markedly more reduction in neutralization of B.1.617.2, suggesting that individuals infected previously by these variants may be more susceptible to reinfection by B.1.617.2. This observation provides important new insights for immunization policy with future variant vaccines in non-immune populations.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1016/j.cell.2021.06.020