Somdej KanokmedhakulRatsami LekphromKwanjai KanokmedhakulChariya HahnvajanawongSureeporn Bua-ArtWeerasak SaksiriratSamran PrabpaiPalangpon KongsaereeKhon Kaen UniversityMahidol University2018-06-112018-06-112012-09-30Tetrahedron. Vol.68, No.39 (2012), 8261-826614645416004040202-s2.0-84865064882https://repository.li.mahidol.ac.th/handle/20.500.14594/13608Four new aristolane sesquiterpenes named nambinones A-C (1-3) and 1-epi-nambinone B (4), a new sesquiterpene, nambinone D (5), a known compound, aurisin A (6) as well as a new dimeric sesquiterpene, aurisin K (7), were isolated from two isolates of luminescent mushroom, Neonothopanus nambi, PW1 and PW2. These structures were established on the basis of spectroscopic evidence. The relative configuration of 6 was determined by X-ray crystallographic analysis. Compounds 6 and 7 exhibited antimalarial activity against Plasmodium falciparum and antimycobacterial activity against Mycobacterium tuberculosis. Compounds 3, 6, and 7 showed cytotoxicity against NCI-H187 cancer cell lines. In addition, 6 and 7 showed cytotoxicity against the cholangiocarcinoma cell lines. © 2012 Elsevier Ltd. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/j.tet.2012.07.057