M. De FostW. ChierakulR. LimpaiboonA. DondorpN. J. WhiteT. Van Der PollAcademic Medical Centre, University of AmsterdamMahidol UniversityUdon Thani Regional HospitalUniversity of Oxford2018-08-242018-08-242007-01-01Clinical Microbiology and Infection. Vol.13, No.4 (2007), 433-436146906911198743X2-s2.0-33847795928https://repository.li.mahidol.ac.th/handle/20.500.14594/25081The plasma concentrations of granzymes are considered to reflect the involvement of cytotoxic T-cells and natural killer cells in various disease states. Interferon (IFN)-γ-inducible protein-10 (IP-10) and monokine induced by IFN-γ (Mig) are members of the non-ELR CXC chemokine family that act on T-cells and natural killer cells. This study revealed that the plasma concentrations of granzyme B (but not granzyme A), IP-10 and Mig were higher in 44 Thai patients with definite or possible leptospirosis than in healthy blood donors. These data suggest that activation of cell-mediated immunity is part of the early host response to leptospirosis. © 2007 European Society of Clinical Microbiology and Infectious Diseases.Mahidol UniversityMedicineArticleSCOPUS10.1111/j.1469-0691.2006.01640.x