Eiji KonishiKobe University School of MedicineMahidol University2018-05-032018-05-032011-12-01Tropical Medicine and Health. Vol.39, No.4 SUPPL. (2011), 63-7113494147134889452-s2.0-84863826505https://repository.li.mahidol.ac.th/handle/20.500.14594/12164Dengue fever (DF) and dengue heemorrhagic fever (DHF) are mosquito-transmitted diseases of global importance. Despite significant research efforts, no approved vaccines or antiviral drugs against these diseases are currently available. This brief article reviews the status of dengue vaccine development, with particular emphasis on the vaccine strategies in more advanced stages of evaluation; these include traditional attenuation, chimerization and engineered attenuation. Several aspects of these vaccine design strategies, including concerns about vaccine candidates inducing infection-enhancing antibodies, are also presented. © 2011 by The Japanese Society of Tropical Medicine.Mahidol UniversityMedicineReviewSCOPUS10.2149/tmh.2011-S01