Takuya YoshiokaYasuhiro IgarashiTakushi NambaShohei UedaIvy Grace Umadhay PaitTakuya NihiraShigeru KitaniToyama Prefectural UniversityOsaka UniversityKochi UniversityMahidol University2022-08-042022-08-042021-05-01Journal of Antibiotics. Vol.74, No.5 (2021), 359-36218811469002188202-s2.0-85099443090https://repository.li.mahidol.ac.th/handle/20.500.14594/78965In our screening program for new biologically active compounds, a new polyene macrolide, lavencidin (1), along with known compound RKGS-A2215A (2), was isolated from the fermentation broth of Streptomyces lavendulae FRI-5 by changing the composition of liquid medium normally used for the strain. Their structures were elucidated by spectral methods (high-resolution fast-atom bombardment mass spectrometry (HRFABMS) and nuclear magnetic resonance (NMR)). Compound 1 includes a conjugated pentaene moiety together with six hydroxy groups and a carboxylic acid as a side chain. Lavencidin (1) showed moderate growth-inhibitory activity against yeast and was cytotoxic against human cancer cell lines with low-micromolar IC50 values.Mahidol UniversityPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1038/s41429-020-00404-z