Ammarin ThakkinstianMark McEvoyUsha ChakravarthySubhabrata ChakrabartiGareth J. McKayEuijung RyuGiuliana SilvestriInderjeet KaurPeter FrancisTakeshi IwataMasakazu AkahoriAstrid ArningAlbert O. EdwardsJohanna M. SeddonJohn AttiaMahidol UniversityUniversity of Newcastle, AustraliaQueen's University BelfastL.V. Prasad Eye Institute IndiaMayo ClinicOHSU School of MedicineNational Hospital Organization, JapanLeibniz Institute of Arteriosclerosis ResearchUniversity of OregonTufts University School of MedicineJohn Hunter Hospital2018-06-112018-06-112012-09-01American Journal of Epidemiology. Vol.176, No.5 (2012), 361-37214766256000292622-s2.0-84865776603https://repository.li.mahidol.ac.th/handle/20.500.14594/14682The authors performed a systematic review of the association of complement component 2(C2)/complement factor B (CFB) gene polymorphisms with age-related macular degeneration (AMD). In total, data from 19 studies published between 2006 and 2011 were pooled for 4 polymorphisms: rs9332739 and rs547154 in the C2 gene and rs4151667 and rs641153 in the CFB gene. Data extraction and assessments for risk of bias were independently performed by 2 reviewers. Allele frequencies and allele and genotypic effects were pooled. Heterogeneity and publication bias were explored. Pooled minor allele frequencies for all 4 SNPs were between 4.7 and 9.6 for all polymorphisms, except for an Indian population in which the C allele at rs9332739 was the major allele. For the C2 polymorphisms, the minor C allele at rs9332739 and the minor T allele at rs547154 carried estimated relative risks (odds ratios) of 0.55 (95 confidence interval (CI): 0.46, 0.65) and 0.47 (95 CI: 0.39, 0.57), respectively. For the CFB polymorphisms, the minor A alleles at rs4151667 and rs614153 carried estimated risks of 0.54 (95 CI: 0.45, 0.64) and 0.41 (95 CI: 0.34, 0.51), respectively. These allele effects contributed to an absolute lowering of the risk of all AMD in Caucasian populations by 2.06.0. This meta-analysis provides a robust estimate of the protective association of C2/CFB with AMD. © 2012 The Author.Mahidol UniversityMedicineReviewSCOPUS10.1093/aje/kws031