Kannan Badri NarayananManaf AliBarry J. BarclayQiang ChengLeandro D'AbronzoRita Dornetshuber-FleissParamita M. GhoshMichael J. Gonzalez GuzmanTae Jin LeePo Sing LeungLin LiSuidjit LuanpitpongEdward RatovitskiYon RojanasakulMaria Fiammetta RomanoSimona RomanoRanjeet Kumar SinhaClement YedjouFahd Al-MullaRabeah Al-TemaimiAmedeo AmedeiDustin G. BrownElizabeth P. RyanAnnamaria ColacciRoslida A. HamidChiara MondelloJayadev RajuHosni K. SalemJordan WoodrickIvana ScovassiNeetu SinghMonica VaccariRabindra RoyStefano ForteLorenzo MemeoSeo Yun KimWilliam H. BissonLeroy LoweHyun Ho ParkYeungnam UniversityUniversiti Sultan Zainal AbidinPlant Biotechnologies IncSouthern Illinois UniversityUniversity of California, DavisUniversitat WienUniversity of Puerto RicoChinese University of Hong KongMahidol UniversityThe Johns Hopkins School of MedicineWest Virginia University Robert C. Byrd Health Sciences CenterUniversita degli Studi di Napoli Federico IIScripps Research InstituteJackson State UniversityUniversity of KuwaitUniversita degli Studi di FirenzeColorado State UniversityEnvironmental Protection and Health Prevention AgencyUniversiti Putra MalaysiaConsiglio Nazionale delle RicercheToxicology Research DivisionCairo UniversityLombardi Comprehensive Cancer CenterChhatrapati Shahuji Maharaj Medical UniversityMediterranean Institute of OncologyKorea Cancer Center HospitalOregon State UniversityGetting to Know Cancer2018-11-232018-11-232015-06-01Carcinogenesis. Vol.36, (2015), S89-S11014602180014333342-s2.0-84937698903https://repository.li.mahidol.ac.th/handle/20.500.14594/35450© The Author 2015. Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically, the up-regulation of prosurvival factors, including oncogenic factors and antiapoptotic signaling pathways, and the down-regulation of proapoptotic factors, including tumor suppressive factors, confers resistance to cell death in tumor cells, which supports the emergence of a fully immortalized cellular phenotype. This review considers the potential relevance of ubiquitous environmental chemical exposures that have been shown to disrupt key pathways and mechanisms associated with this sort of dysfunction. Specifically, bisphenol A, chlorothalonil, dibutyl phthalate, dichlorvos, lindane, linuron, methoxychlor and oxyfluorfen are discussed as prototypical chemical disruptors; as their effects relate to resistance to cell death, as constituents within environmental mixtures and as potential contributors to environmental carcinogenesis.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyReviewSCOPUS10.1093/carcin/bgv032