Yongwimon LenburyPornsarp PornsawadMahidol University2018-06-212018-06-212005-03-01Mathematical Medicine and Biology. Vol.22, No.1 (2005), 15-33147785992-s2.0-17144425726https://repository.li.mahidol.ac.th/handle/20.500.14594/16369The present work develops and analyses a model system of delay-differential equations which describes the core dynamics of the stress-responsive hypothalamus-pituitary-adrenal axis. This neuroendocrine ensemble exhibits prominent pulsatile secretory patterns governed by nonlinear and time-delayed feedforward and feedback signal interchanges. Formulation and subsequent bifurcation analysis of the model provide a qualitative and mathematical frame work for a better understanding of the delayed responsive mechanisms as well as the dynamic variations in different pathological situations. © The Author 2005. Published by Oxford University Press on behalf of the Institute of Mathematics and its Applications. All Rights Reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyEnvironmental ScienceImmunology and MicrobiologyMathematicsMedicineNeurosciencePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1093/imammb/dqh020