Suteera ThomsonPetcharin SrivatanakulEdwin A. MirandMahidol UniversityRoswell Park Cancer Institute2018-04-192018-04-191974-01-01Proceedings of the Society for Experimental Biology and Medicine. Vol.145, No.4 (1974), 1329-133215353699003797272-s2.0-0016275441https://repository.li.mahidol.ac.th/handle/20.500.14594/10609Growth kinetics of certain hemopoietic cells and target cells of Friend spleen focus-forming virus (SFFV) were studied in mice treated with supralethal irradiation (900 rads) and infusion of bone marrow cells, or with myleran. In supra-lethally irradiated mice, the presence of SFFV and SFFV-induced tumor cells corresponded with that of normal colony-forming cells but with somewhat different growth rates. In myleran-treated mice, however, SFFV and SFFV-induced tumor cells were present when normal colony-forming cells were not observed. Thus, the results indicate that normal colony-forming cells were probably not the target cells for SFFV. The results are consistent with the view that at least two or possibly three types of target cells were present; the target cells for SFFV replication might be different from those for SFFV-induced tumor cells. © 1974, SAGE Publications. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.3181/00379727-145-38007