Corchorusides A and B, new flavonol glycosides as α-glucosidase inhibitors from the leaves of Corchorus olitorius

Preecha PhuwapraisirisanThanchanok PuksasookUdom KokpolKhanit SuwanboriruxMahidol UniversityChulalongkorn University2018-09-132018-09-132009-10-21Tetrahedron Letters. Vol.50, No.42 (2009), 5864-5867004040392-s2.0-69249223455https://repository.li.mahidol.ac.th/handle/20.500.14594/27131Corchorus olitorius, a highly fibrous vegetable commonly known as moroheiya, has long been recognized for its hypoglycemic activity. Bioassay-guided fractionation of the leaf extract led to the isolation of two new flavonol glycosides named corchorusides A and B, in addition to a major component, capsugenin-25,30-O-β-diglucopyranoside. Corchoruside A comprises a kaempferol moiety connected with caffeic acid, glucose, and a rare methyl glucuronate (MeGlcA). The occurrence of a caffeoyl moiety in corchoruside A enhanced significantly its inhibitory effect toward α-glucosidase compared to that in corchoruside B. © 2009 Elsevier Ltd. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsCorchorusides A and B, new flavonol glycosides as α-glucosidase inhibitors from the leaves of Corchorus olitoriusArticleSCOPUS10.1016/j.tetlet.2009.08.014