Kittikool T.Viriyanukul T.Phakdeeyothin K.Yotphan S.Mahidol University2025-02-202025-02-202025-01-01Asian Journal of Organic Chemistry (2025)https://repository.li.mahidol.ac.th/handle/20.500.14594/105354Site-selective direct acetoxylation of pyrazolones was accomplished by utilizing an easy-to-handle (diacetoxyiodo)benzene (PIDA) as the sole acetoxylating reagent. In the presence of Pd(OAc)2 catalyst, the 4-acetoxylated pyrazolone product was exclusively formed. Meanwhile, in the absence of Pd(OAc)2, the pyrazolone methyl acetate product was obtained over the Csp2−H bond functionalization. Both approaches have been successfully applied to various pyrazolone substrates, giving the corresponding products in moderate to high yields under mild conditions.ChemistryArticleSCOPUS10.1002/ajoc.2024008082-s2.0-8521755286421935815