Sornchai LooareesuwanPoonkasem CharoenpanMay HoNicholas J. WhiteJuntra KarbwangDanai BunnagTranakchit HarinasutaMahidol UniversityNuffield Department of Clinical MedicineUniversity of Calgary2018-06-142018-06-141990-01-01Journal of Infectious Diseases. Vol.161, No.3 (1990), 577-58015376613002218992-s2.0-0025220120https://repository.li.mahidol.ac.th/handle/20.500.14594/16167A 24-year-old man with severe Plasmodium falciparum malaria died after 77 h of treatment with full parenteral doses of quinine. His peripheral parasitemia at death exceeded the level on admission. Plasma concentrations of quinine were abnormally low throughout. This case emphasizes the importance of pharmacokinetic factors in determining the therapeutic response in severe P. falciparum malaria. © 1990, University of Chicago. All rights reserved.Mahidol UniversityMedicineArticleSCOPUS10.1093/infdis/161.3.577