S. PuavilaiS. ChuthaN. PolnikornP. TimpatanapongP. TasanapraditS. CharuwichitratanaA. BoonthanomH. WongwaisayawanMahidol University2018-10-122018-10-121984-12-01Journal of the Medical Association of Thailand. Vol.67, No.7 (1984), 404-408012522082-s2.0-0021745207https://repository.li.mahidol.ac.th/handle/20.500.14594/30645Fifty-seven patients with different types of leprosy treated with dapsone 50-100 mg per day were evaluated in regard to the frequency, onset and etiology of anemia. Fifty-one patients had normal G-6-PD, six patients had complete deficiency of G-6-PD. Significant anemia developed in 40 cases out of 51 patients with normal G-6-PD (P<0.05). The onset of significant anemia in this group was one month after dapsone administration and continued throughout the course of treatment for one year. The methemoglobin level rose significantly (P < 0.01) in correlation with the dose of dapsone administered. Seventeen patients had hemolysis, 13 had Heinz bodies and one had positive direct Coombs' test. Hemolytic anemia developed in 5 out of 6 patients with complete deficiency of G-6-PD, but not severe enough to necessitate discontinuation of treatment.Mahidol UniversityMedicineArticleSCOPUS