Namphung VongvanichPrasat KittakoopPanarat CharoenchaiSutichai IntamasKanlayanee SriklungYodhathai ThebtaranonthMahidol UniversityThailand National Center for Genetic Engineering and BiotechnologyChulabhorn Research Institute2018-08-202018-08-202006-12-01Planta Medica. Vol.72, No.15 (2006), 1427-1430003209432-s2.0-33846213131https://repository.li.mahidol.ac.th/handle/20.500.14594/22853Chemical exploration of Camchaya calcarea (family Compositae) has led to the isolation of nine known sesquiterpene lactones 1-9, together with caffeic acid methyl ester 10. Sesquiterpenes 1, 2, 3, 4, 5, 7, and 8 exhibited moderate antiplasmodial activity, but showed potent antimycobacterial activity. Interestingly, the cytotoxicity of sesquiterpene lactones 1, 2, and 4 towards small-cell lung cancer cell line (NCI-H187) is stronger (two orders of magnitude) than towards the Vero cell line. Caffeic acid methyl ester (10) was cytotoxic against NCI-H187 and BC cell lines, however the ester 10 showed only mild antimycobacterial activity. © Georg Thieme Verlag KG Stuttgart.Mahidol UniversityAgricultural and Biological SciencesChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1055/s-2006-951711