Bonkoch TarnchompooChachanat ThebtaranonthYodhathai ThebtaranonthMahidol University2018-06-142018-06-141987-01-01Tetrahedron Letters. Vol.28, No.52 (1987), 6675-6678004040392-s2.0-0023579210https://repository.li.mahidol.ac.th/handle/20.500.14594/15321Diene 1 readily adds primary amines to give 2 which can cyclize either in a Michael addition fashion or via a displacement reaction to give, respectively, pyrrolidine 3 or methylene lactam 4 which further isomerizes to 5 under the employed reaction conditions. Compound 4 can be obtained as the sole product from the reaction of diene precursor 7 with amines followed by vacuum pyrolysis. © 1987.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsPyrrolidine and α-methylene-α-lactam from the cyclization of α-(alkylaminoethyl)acrylate: Synthesis of aza-sarkomycinsArticleSCOPUS10.1016/S0040-4039(00)96943-0