Kerati IssarapayupSorawit PowtongsookPrasert PavasantChulalongkorn UniversityMahidol UniversityThailand National Science and Technology Development Agency2018-09-132018-09-132009-07-15Journal of Biotechnology. Vol.142, No.3-4 (2009), 227-232016816562-s2.0-67650088748https://repository.li.mahidol.ac.th/handle/123456789/27179The novel flat panel airlift photobioreactor (FP-ALPBR) was proposed as an alternative system for the cultivation of Haematococcus pluvialis NIES-144. Changes in the efficiency of the system were tested in response to variations in two engineering parameters: the ratio between the downcomer and riser cross-sectional areas (Ad/Ar) and the size of the system (as determined by the length of the panel) and to one operating parameter: the superficial gas velocity (usg). The best growth performance was obtained by operating the system at a superficial velocity of 0.4 cm s-1and with a downcomer-to-riser cross-sectional area ratio of 0.4. The 17-l FP-ALPBR system was capable of giving reasonable growth characteristics with a maximum cell density of 4.1 × 105cell ml-1and specific growth rate of 0.52 day-1being achieved. A similar level of performance was obtained from the 90-l FP-ALPBR system, i.e., cell density = 40 × 104cell ml-1but with a slight decrease in specific growth rate to 0.39 day-1. The performances of these two differently sized FP-ALPBRs were compared with two conventional cylindrical airlift photobioreactors (C-ALPBRs) of different dimensions. The 90-l FP-ALPBR exhibited reasonably good performance when compared with the two 17-l systems (both C- and FP-ALPBRs); however, the best growth rate was observed using the 3-l C-ALPBR. Semi-continuous cultures, which could be periodically harvested at a reasonably high growth rate, were successfully created. Of all the systems investigated in this study, the 90-l FP-ALPBR was found to be the most cost-effective, as it could cultivate 18 g of alga for approximately US$ 21. © 2009 Elsevier B.V. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyImmunology and MicrobiologyArticleSCOPUS10.1016/j.jbiotec.2009.04.014