Mohamed D. DaripStitaya SirisinhaAdrian J. LambMahidol University2018-06-012018-06-011979-01-01Proceedings of the Society for Experimental Biology and Medicine. Vol.161, No.4 (1979), 600-60415353699003797272-s2.0-0018686129https://repository.li.mahidol.ac.th/handle/20.500.14594/13158The effect of vitamin A deficiency on susceptibility to infection by A. cantonensis was studied using rats reared by a procedure enabling the synchronous induction of vitamin A deficiency and the stringent control of both dietary protein and energy input. Vitamin A-deficient (A - ) rats were more susceptible to infection by third-stage larvae than (A + ) controls, as revealed from mortality rate, survival period, and/or worm recovery. Evidence was presented to show that more larvae were able to penetrate the intestinal mucosa of A - rats than that of A + controls, a finding that is consistent with the fact that one of the functions of vitamin A is to maintain the morphological and functional integrity of the mucosa. Moreover, following a primary infection A - rats developed a lower degree of protective immunity than A + control. Animals that were initially exposed to the parasite during the A + state had a longer survival period and a lower worm burden than the group that was deficient in vitamin A during the early period of initial infection. © 1979, SAGE Publications. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.3181/00379727-161-40605