Tim J C AndersonShalini NairStandwell NkhornaJeff T. WilliamsMallika ImwongPoravuth YiDuong SocheatDebashish DasKesinee ChotivanichNicholas P J DayNicholas J. WhiteArjen M. DondorpTexas Biomedical Research InstituteMahidol UniversityChurchill HospitalNatl. Ctr. Parasitol.2018-09-242018-09-242010-05-01Journal of Infectious Diseases. Vol.201, No.9 (2010), 1326-1330002218992-s2.0-77950943615https://repository.li.mahidol.ac.th/handle/20.500.14594/29691In western Cambodia, malaria parasites clear slowly from the blood after treatment with artemisinin derivatives, but it is unclear whether this results from parasite, host, or other factors specific to this population. We measured heritability of clearance rate by evaluating patients infected with identical or nonidentical parasite genotypes, using methods analogous to human twin studies. A substantial proportion (56%-58%) of the variation in clearance rate is explained by parasite genetics. This has 2 important implications: (1) selection with artemisinin derivatives will tend to drive resistance spread and (2) because heritability is high, the genes underlying parasite clearance rate may be identified by genome-wide association. © 2010 by the Infectious Diseases Society of America. All rights reserved.Mahidol UniversityMedicineArticleSCOPUS10.1086/651562