Kuldeep DhamaKhan SharunMudasir B. GugjooRuchi TiwariMahmoud AlagawanyMohd Iqbal YatooPallavi ThakurHafiz M.N. IqbalWanpen ChaicumpaIzabela MichalakShaaban S. ElnesrMayada R. FaragU.P. Pandit Deen Dayal Upadhyaya pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan SansthanPatanjali Yog Peeth Trust, HaridwarSKUAST-Kashmir, Faculty of Veterinary Sciences and Animal HusbandryFayoum UniversityWrocław University of Science and TechnologySher-e-Kashmir University of Agricultural Sciences and Technology of KashmirFaculty of Medicine Siriraj Hospital, Mahidol UniversityTecnologico de MonterreyIndian Veterinary Research InstituteZagazig University2022-08-042022-08-042021-01-01Food Reviews International. (2021)15256103875591292-s2.0-85103029695https://repository.li.mahidol.ac.th/handle/20.500.14594/75793Herbs and plant metabolites/extracts are gaining wide attention owing to their multiple beneficial health effects, medicinal values, and nutraceutical properties, particularly in the present era of emerging drug resistance and untold side effects of chemical drugs. Ocimum basilicum L., known as sweet basil, has been studied for its various potent effects including, antimicrobial, antifungal, insecticidal, antiparasitic, antioxidant, immunomodulatory, anti-inflammatory, hepatoprotective, anti-osteoporotic, cardioprotective, neuroprotective, anti-cancer, and other beneficial health effects. Thus, this herb has the potential for treating a myriad of ailments/diseases and disorders in both humans and animals. Different bioactive chemical compounds have been identified from O. basilicum, such as linalool, geraniol, methyl eugenol, methyl chavicol, p-allylanisole, 1,8–cineole, trans–α–bergamotene, and neryl acetate. Recent advances in nanotechnology can further be utilized for improving the multiple beneficial activities of the crude extract of O. basilicum. This review highlights the phytoconstituent profile, medicinal values, therapeutic applications, and salient beneficial health aspects of O. basilicum, which would help in further exploring this wonderful herb for designing effective pharmaceuticals, drugs and medicines for safeguarding various health issues of humans and animals, while supporting its traditional use in curing various ailments, diseases and health-promoting effects.Mahidol UniversityAgricultural and Biological SciencesChemical EngineeringReviewSCOPUS10.1080/87559129.2021.1900230