Vip ViprakasitSuthida KankirawatanaPravit AkarasereenontKritvikrom DurongpisitkulSirikul ChotewuttakornVoravarn S. TanphaichitrWeatherall Institute of Molecular MedicineMahidol UniversityJohn Radcliffe HospitalUniversity of Oxford2018-07-242018-07-242002-07-04American Journal of Hematology. Vol.70, No.3 (2002), 260-262036186092-s2.0-0036089573https://repository.li.mahidol.ac.th/handle/20.500.14594/20462We studied levels of plasma endothelin-1 (ET-1) in 25 β-thalassemia/Hb E patients before and after blood transfusion. Baseline ET-1 levels in these patients were significantly higher than in normal controls (10.17 ± 2.1 pg/mL vs. 8.9 ± 2.0 pg/mL, P < 0.05). After blood transfusion, levels of plasma ET-1 tend to slightly increase during the first 24 hr but significantly decline at the 7thday to levels (8.01 ± 1.7 pg/mL) which do not differ from those of controls. This study highlights a different alteration of plasma ET-1 in patients with β-thalassemia compared to that of patients with sickle-cell anemia. © 2002 Wiley-Liss, Inc.Mahidol UniversityMedicineArticleSCOPUS10.1002/ajh.10129