S. PhornchirasilpO. P. MatangkasombutMahidol University2018-10-122018-10-121982-01-01Hormone and Metabolic Research. Vol.14, No.4 (1982), 207-209001850432-s2.0-0020036297https://repository.li.mahidol.ac.th/handle/20.500.14594/30300The effect of adrenalectomy on the basal cardiac c-AMP level and the elevated c-AMP level induced by intravenous administration of isoprenaline (10 mcg/kg) were determined by radio-protein assay. The basal cardiac c-AMP level was not altered by adrenalectomy. But the cardiac c-AMP responses to isoprenaline were significantly less in adrenalectomized rats, maintained with 1% sodium chloride solution for one week; this effect, however, disappeared when animals were maintained for 2 or 4 weeks. This could not be restored by acute administration of dexamethasone (100 mcg/rat). The possible reasons for these effects of adrenalectomy are discussed.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineArticleSCOPUS10.1055/s-2007-1018970