Stuart D. BlacksellKemajittra JenjaroenRattanaphone PhetsouvanhVanaporn WuthiekanunNicholas P.J. DayPaul N. NewtonWei Mei ChingMahidol UniversityUniversity of OxfordMahosot HospitalNaval Medical Research Center2018-09-242018-09-242010-02-01Clinical and Vaccine Immunology. Vol.17, No.2 (2010), 263-2661556679X155668112-s2.0-75749146669https://repository.li.mahidol.ac.th/handle/20.500.14594/28796Using archived samples, we assessed the diagnostic capacity of a rapid immunochromatographic test (ICT) for the detection of Orientia tsutsugamushi IgM and total antibodies to aid with the diagnosis of acute scrub typhus infection in febrile patients in Laos. The sensitivity and the specificity of the ICT for the detection of IgM were 96.8% (121/125 samples; 95% confidence interval [CI], 92.1 to 99.1%) and 93.3% (98/105 samples; 95% CI, 86.7 to 97.3%), respectively. For the detection of total antibodies, the sensitivity was 97.6% (122/125 samples; 95% CI, 93.1 to 99.5%), but the specificity was much lower, at 71.4% (75/105 samples; 95% CI, 61.8 to 79.8%). Copyright © 2010, American Society for Microbiology. All Rights Reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyImmunology and MicrobiologyMedicineArticleSCOPUS10.1128/CVI.00448-08