D. PereraM. A. YusofY. PodinM. H. OoiN. T.T. ThaoK. K. WongA. ZakiK. B. ChuaY. A. MalikP. V. TuN. T.K. TienP. PuthavathanaP. C. McMinnM. J. CardosaUniversiti Malaysia SarawakInstitute for Medical Research Kuala LumpurSibu HospitalPasteur Institute in Ho Chi Minh CityUniversiti Kebangsaan MalaysiaDr Soliman Fakeeh HospitalMakmal Kesihatan Awam Kebangsaan, MalaysiaInternational Medical UniversityMahidol UniversityTelethon Kids Institute2018-08-242018-08-242007-06-01Archives of Virology. Vol.152, No.6 (2007), 1201-1208030486082-s2.0-34249066220https://repository.li.mahidol.ac.th/handle/123456789/24551A phylogenetic analysis of VP1 and VP4 nucleotide sequences of 52 recent CVA16 strains demonstrated two distinct CVA16 genogroups, A and B, with the prototype strain being the only member of genogroup A. CVA16 G-10, the prototype strain, showed a nucleotide difference of 27.7-30.2% and 19.9-25.2% in VP1 and VP4, respectively, in relation to other CVA16 strains, which formed two separate lineages in genogroup B with nucleotide variation of less than 13.4% and less than 16.3% in VP1 and VP4, respectively. Lineage 1 strains circulating before 2000 were later displaced by lineage 2 strains. © 2007 Springer-Verlag.Mahidol UniversityImmunology and MicrobiologyArticleSCOPUS10.1007/s00705-006-0934-5