Jinho YuKangmo AhnYoun Ho ShinKyung Won KimDong In SuhHo Sung YuMi Jin KangKyung Shin LeeSeo Ah HongKil Yong ChoiEun LeeSong I. YangJu Hee SeoByoung Ju KimHyo Bin KimSo Yeon LeeSuk Joo ChoiSoo Young OhJa Young KwonKyung Ju LeeHee Jin ParkPil Ryang LeeHye Sung WonSoo Jong HongUniversity of Ulsan, College of MedicineSungKyunKwan University, School of MedicineCollege of Medicine, Pochon CHA UniversityYonsei University College of MedicineSeoul National University College of MedicineMahidol UniversityKorea Cancer Center HospitalInje University Paik HospitalHallym University, College of Medicine2018-12-112019-03-142018-12-112019-03-142016-01-01Allergy, Asthma and Immunology Research. Vol.8, No.1 (2016), 41-4820927363209273552-s2.0-84946740606https://repository.li.mahidol.ac.th/handle/123456789/40906© The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease. Purpose: Although home renovation exposure during childhood has been identified as a risk factor for the development of allergy, there is limited information on the association between prenatal exposure to home renovation and cord blood (CB) IgE response. The aims of this study were to identify the effect of prenatal exposure to home renovation on CB IgE levels, and to investigate whether this exposure interacts with neonatal genes and whether the effect can be modified by maternal atopy. Methods: This study included 1,002 mother-neonate pairs from the COhort for Childhood Origin of Asthma and allergic diseases (COCOA). Prenatal environmental factors were collected using a questionnaire. The levels of CB IgE were measured by the ImmunoCAP system, and DNA was extracted from CB. Results: Exposure to home renovation during the prenatal period was associated with significantly higher levels of CB IgE only in neonates from atopic mothers, and the effect of renovation exposure on CB IgE levels persisted from 31 months before birth. Furthermore, prenatal exposure to home renovation increased the risk of CB IgE response interacting with polymorphisms of NRF2 and GSTP1 genes only in neonates from atopic mothers. Conclusions: Maternal atopy modified the effect of prenatal exposure to home renovation on CB serum IgE response as well as the interaction between the exposure and neonatal genes involved in the oxidative stress pathway. These findings suggest that the genetically susceptible offspring of atopic mothers may be more vulnerable to the effect of prenatal exposure to home renovation on the development of allergy.Mahidol UniversityImmunology and MicrobiologyArticleSCOPUS10.4168/aair.2016.8.1.41