Ampol MitrevejNuttanan SinchaipanidNuttawat NatpoolwatNarakorn NaratikornritMahidol University2018-07-042018-07-041998-01-01Drug Development and Industrial Pharmacy. Vol.24, No.8 (1998), 793-796036390452-s2.0-0031819923https://repository.li.mahidol.ac.th/handle/20.500.14594/18347Phenylpropanolamine hydrochloride (PPA) pellets were prepared in a fluidized-bed rotary granulator. Microcrystalline cellulose and distilled water were used as pelletization enhancer and binder, respectively. The pellets were coated with methacrylate ester copolymer (Eudragit(R) RS 100) solution containing a 1:1 ratio mixture of triethyl citrate and castor oil as plasticizers. The addition of approximately 30% microcrystalline cellulose and 2% croscarmellose sodium to the 50% coated pellets produced fast disintegrating tablets. Dissolution profiles of both pellets and their respective matrix tablets were comparable and conformed to the USP dissolution requirement for PPA extended-release capsules.Mahidol UniversityChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.3109/03639049809082728