Sopee PoomsawatJirapa PunyasinghPaisarn VejchapipatMahidol UniversityChulalongkorn University2018-08-242018-08-242007-11-01Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology. Vol.104, No.5 (2007), 666-675107921042-s2.0-35349001607https://repository.li.mahidol.ac.th/handle/20.500.14594/24408Objective: The objective was to characterize the expression of BMCs (laminins 1 and 5, collagen type IV, and fibronectin) in ameloblastomas, calcifying cystic odontogenic tumors (CCOTs), and adenomatoid odontogenic tumors (AOTs). Study design: BMCs were analyzed in 14 ameloblastomas, 7 CCOTs, and 7 AOTs using immunohistochemistry. Results: In normal oral mucosa, linear deposits of these proteins were found at the epithelial-mesenchymal junction, but not in epithelial cytoplasm. In all tumors studied, linear deposits of all proteins were found at the epithelial-mesenchymal junction; laminin 1 was expressed in all tumor cells, regardless of cell types. For CCOTs, laminin 5 was found faintly in suprabasal cells, but expressed strongly in ghost cells. For AOTs, laminin 5 strongly decorated tumor cells adjacent to mineralization. Conclusions: Laminin 1 may be a marker for odontogenic epithelium. Additionally, laminin 5 may be involved in ghost cell formation and initiation of calcification. © 2007 Mosby, Inc. All rights reserved.Mahidol UniversityDentistryMedicineArticleSCOPUS10.1016/j.tripleo.2006.08.025