Y. HerabutyaP. O-PrasertsawatMahidol University2018-07-042018-07-041998-02-01International Journal of Gynecology and Obstetrics. Vol.60, No.2 (1998), 161-165002072922-s2.0-0032007676https://repository.li.mahidol.ac.th/handle/20.500.14594/18577Objective: To find the effective dose of intravaginal misoprostol to induce second trimester abortion. Methods: Intravaginal misoprostol in 200-μg, 400-μg and 600-μg doses were applied at 12-h intervals in 150 consecutive pregnancies. Results: The 48-h successful abortion rate was 70.6%, 82% and 96%, respectively, and these rates were unaffected by parity. The mean induction to abortion interval was 45.0 ± 41.5, 33.4 ± 34.9 and 22.3 ± 14.3 h, respectively. The mean dose of misoprostol required to induce abortion was 416.7 μg, 772.8 μg and 1296 μg. The rate of nausea and vomiting was 3.9%, 12% and 20%. The diarrhea occurrence rate was 0%, 6% and 22% with temperature elevation 0%, 2% and 28%, respectively. The rate of incomplete abortion was 35.3%, 28% and 22%, respectively. Conclusion: The 600-μg dose is more effective as an abortifacient agent for second trimester abortion in terms of 48-h success rate and the rate of incomplete abortion but with more side effects. However, the side effects were mild and did not warrant any specific treatment.Mahidol UniversityMedicineArticleSCOPUS10.1016/S0020-7292(97)00244-0