Tejapira K.Suchonwanit P.Mahidol University2023-07-222023-07-222023-01-01Clinical, Cosmetic and Investigational Dermatology Vol.16 (2023) , 1729-1735https://repository.li.mahidol.ac.th/handle/20.500.14594/88030Familial dyskeratotic comedones (FDC) is an autosomal dominant inherited skin disorder characterized by generalized multiple discrete comedone-like hyperkeratotic papules. The disease demonstrates a distinct histopathologic feature of dyskeratosis of the crater-like invaginated epidermis or follicle-like structures with or without acantholysis. Despite its asymptomatic and benign course, the condition is refractory to treatment. Herein, we report a case of a 54-year-old female presenting with progressively developed generalized multiple hyperkeratotic papules with central keratin plugs on the trunk and extremities for 20 years. A definite diagnosis was made by clinical manifestations and histopathological examination. The lesions were slightly improved after 3 months of topical retinoids and urea cream treatments. Besides, we first describe dermoscopic findings of FDC and reviewed 21 previously reported FDC cases from 11 families in the literature.MedicineArticleSCOPUS10.2147/CCID.S4207232-s2.0-8516437388411787015