Napatawn Tandhanand-BanchuinWannapa KespichayawatanaSathit VannasaengChatri BanchuinTawee LaohapandSukij PanpimarnmasKovit PattanapanyasatSuttipant SarasombathH. Kyle WebsterFaculty of Medicine, Siriraj Hospital, Mahidol UniversityMahidol UniversityRajavithi HospitalArmed Forces Research Institute of Medical Sciences, Thailand2018-08-102018-08-101992-01-01Diabetes Research and Clinical Practice. Vol.18, No.1 (1992), 17-21016882272-s2.0-0026722372https://repository.li.mahidol.ac.th/handle/20.500.14594/22277A case of fibrocalculous pancreatic diabetes (FCPD) is reported for which antibody and cellular immune characteristics were determined. The patient, a Thai woman, had serum islet cell antibodies (ICA) that were detected by both immunoperoxidase staining and an indirect enzyme-linked immunosorbent assay (ELISA). Serum anti-human insulin antibodies were negative by a displacement ELISA. Lymphoproliferation assay against pancreatic antigen prepared from a blood group O cadaveric donor was positive. Increased CD8+lymphocytes were observed using direct immunofluorescence staining and flow cytometry. CD4+T lymphocytes, B lymphocytes and NK cells were within normal levels. These findings provide evidence for autoimmunity to pancreatic antigens in a patient with fibrocalculous pancreatic diabetes. © 1992.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineArticleSCOPUS10.1016/0168-8227(92)90050-2