May Thazin ThantNutputsorn ChatsumpunWanwimon MekboonsonglarpBoonchoo SritularakKittisak LikhitwitayawuidChulalongkorn UniversityMahidol University2020-11-182020-11-182020-10-25Molecules (Basel, Switzerland). Vol.25, No.21 (2020)142030492-s2.0-85094830587https://repository.li.mahidol.ac.th/handle/20.500.14594/59866Two new compounds, dihydrodengibsinin (1) and dendrogibsol (2), were isolated from the whole plant of Dendrobium gibsonii, together with seven known compounds (3-9). The structures of the new compounds were elucidated by their spectroscopic data. All these isolates were evaluated for their α-glucosidase inhibitory activities. Dendrogibsol (2) and lusianthridin (7) showed strong α-glucosidase inhibitory activity when compared with acarbose. An enzyme kinetic study revealed that dendrogibsol (2) is a noncompetitive inhibitor of α-glucosidase.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryArticleSCOPUS10.3390/molecules25214931