Structures of cordypyridones A-D, antimalarial N-hydroxy- and N-methoxy-2-pyridones from the insect pathogenic fungus Cordyceps nipponica

M. IsakaM. TanticharoenPalangpon KongsaereeYodhathai ThebtaranonthThailand National Center for Genetic Engineering and BiotechnologyMahidol University2018-09-072018-09-072001-07-13Journal of Organic Chemistry. Vol.66, No.14 (2001), 4803-4808002232632-s2.0-0035854290https://repository.li.mahidol.ac.th/handle/20.500.14594/26506Bioassay-guided fractionation of the extracts from the insect pathogenic fungus Cordyceps nipponica BCC 1389 led to the isolation of N-hydroxy- and N-methoxy-2-pyridones, cordypyridones A-D (1-4). Structures of these compounds, including absolute configuration, were determined by spectroscopic methods, chemical conversions and single-crystal X-ray diffraction analyses. Codypyridones A and B, atropisomers of each other, exhibited potent in vitro antimalarial activity with IC50 values of 0.066 and 0.037 μ/mL, respectively, while their cytotoxicity was much weaker.Mahidol UniversityChemistryStructures of cordypyridones A-D, antimalarial N-hydroxy- and N-methoxy-2-pyridones from the insect pathogenic fungus Cordyceps nipponicaArticleSCOPUS10.1021/jo0100906