Woodrow, Charles JGardner, Kate BBustamante, Leyla YMahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit (MORU)2017-11-092017-11-092012Malaria Journal. Vol.11, (2012),186https://repository.li.mahidol.ac.th/handle/123456789/3100A recent paper in Malaria Journal suggests that a high proportion of Plasmodium falciparum isolates found in travellers returning from a range of African countries carry the PfATP6 A623E S769N haplotype, and that this genotype is associated with artemether resistance. Such a finding would represent a substantial departure from the extensive literature reporting these individual mutations to be very rare, with the double mutation never documented. The number of isolates screened to obtain these double mutants is unstated, but highly relevant, not least because selection of isolates could have introduced significant confounders, such as timing of in vitro testing. An additional concern relates to the location of sequencing primers used to assess these positions. In the absence of clear information on these fundamental questions it would be appropriate to treat the findings with caution.engMahidol UniversityPlasmodium falciparum, traveller isolates, PfATP6 A623E S769N haplotype, artemether resistance, Open Access articleResearch ArticleBioMed Central