Thararat NualsanitPleumchitt RojanapanthuWandee GritsanapanThiwanporn KwankitpranitiKyung Won MinSeung Joon BaekUniversity of Tennessee College of Veterinary MedicineMahidol UniversityThailand Ministry of Public Health2018-05-032018-05-032011-01-01Inflammation and Allergy - Drug Targets. Vol.10, No.6 (2011), 455-463187152812-s2.0-81155126242https://repository.li.mahidol.ac.th/handle/20.500.14594/12100Morinda citrifolia L. (Rubiaceae), commonly called noni, is a traditional folk medicinal plant with a long history of use for several diseases. Its anti-inflammation activity has been proposed, but detailed knowledge of this anti-inflammation mechanism remains unclear. Here, we investigated the effects of noni extract and its major bioactive component damnacanthal on anti-inflammation in vivo as well as in vitro. Our data demonstrate that noni extract and its bioactive component damnacanthal exhibit suppression of inflammation as evidenced by the suppression of paw and ear edema in rats and mice, and down-regulation of lipopolysaccharide-induced nuclear factor-KB (NF-kB) activity, respectively. As a result, the expression of pro-cytokines, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) were suppressed in the presence of damnacanthal. These results provide a potential use of damnacanthal in the treatment of inflammatory-related diseases. © 2011 Bentham Science Publishers.Mahidol UniversityImmunology and MicrobiologyMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.2174/187152811798104908