Somdej KanokmedhakulKwanjai KanokmedhakulKomkrich NambuddeePalangpon KongsaereeKhon Kaen UniversityMahidol University2018-07-242018-07-242004-06-01Journal of Natural Products. Vol.67, No.6 (2004), 968-972016338642-s2.0-3042536582https://repository.li.mahidol.ac.th/handle/20.500.14594/21078Two new flavanones (1 and 2), a new flavan (3), and a new rare dibenzocycloheptene derivative (4) together with a known flavan, 4′-hydroxy-2″,2″dimethyl -pyranoflavan (5), were isolated from the roots of Dendrolobium lanceolatum. Their structures were established on the basis of spectral evidence, and an X-ray analysis was performed to confirm the structure of 4. Compounds 1-3 exhibited antimalarial activity with IC 50 values of 2.6, 3.3, and 3.1 μg/mL, respectively. Compounds 1-5 showed moderate antimycobacterial activity with MIC values of 6.3, 12.5, 25, 25, and 50 μg/mL, respectively. In addition, 1 showed strong cytotoxicity against cancer cell lines KB, BC, and NCI-H187 with IC50 values of 1.2, 1.6, and 0.6 μg/mL, respectively, while 2 showed moderate cytotoxicity against the NCI-H187 cell line with an IC50 value of 8.1 μg/mL.Mahidol UniversityAgricultural and Biological SciencesChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1021/np030519j