Piyarat GovitrapongParichart BoontemPatcharee KooncumchooSirinthorn PinwehaJatuporn NamyenYupin SanvarindaSmith VatanatunyakumMahidol UniversityThanyarak hospital2018-09-242018-09-242010-01-01Addiction Biology. Vol.15, No.1 (2010), 100-10213691600135562152-s2.0-71949105326https://repository.li.mahidol.ac.th/handle/20.500.14594/29867Amphetamine derivatives have been shown to be a potential brain neurotoxin based on the production of free radicals that occurs after administration. The purpose of this study was to examine the lipid peroxidation and antioxidant enzymes in the blood of amphetamine users. The plasma lipid peroxidation was determined and reported as thiobarbituric acid reactive substance and was significantly increased (+21%), whereas the activities of the erythrocyte antioxidant enzymes glutathione peroxidase, catalase, and superoxide dismutase were significantly decreased (-32%, -14% and -31%, respectively) in amphetamine users. These results implicated the potential role of oxidative stress in amphetamine-induced neurotoxicity. © 2009 Society for the Study of Addiction.Mahidol UniversityMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1111/j.1369-1600.2009.00176.x