Somchai ChutipongtanateSupawat ChatchenJisnuson SvastiMahidol UniversityChulabhorn Research InstituteChulabhorn Graduate Institute2018-12-212019-03-142018-12-212019-03-142017-07-01Proteomics - Clinical Applications. Vol.11, No.7-8 (2017)18628354186283462-s2.0-85017227344https://repository.li.mahidol.ac.th/handle/20.500.14594/41852© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Plasma is a rich source of biomarkers with clinical relevance. However, the wide dynamic range of protein concentration hinders the detection of low abundance proteins. Plasma prefractionation methods serve as indispensable tools to reduce plasma complexity, allowing the opportunity to explore tissue-derived proteins which leak into the circulation. This review summarizes common approaches in plasma prefractionation methods for proteomic analysis and then discusses some considerations in plasma prefractionation for clinical applications, reviewing some examples of its use in clinical situations.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyReviewSCOPUS10.1002/prca.201600135