Rodjana ChunhabunditSongsak SrianujataAhnond BunyaratvejRatchanee KongkachuichaiJutamadd SatayavivadSming KaojarernMahidol UniversityNational Research Council of Thailand2018-05-032018-05-032011-02-01Journal of the Medical Association of Thailand. Vol.94, No.2 (2011), 164-17101252208012522082-s2.0-79952318273https://repository.li.mahidol.ac.th/handle/20.500.14594/12688Background: Chronic dietary cadmium (Cd) exposure results in kidney dysfunction and decrease in bone mineral density. Objective: To determine and compare the bioavailability of Cd from vegetable and animal-based foods. Material and Method: Caco-2 cells were exposed to Cd in boiled pig kidney, ark shell, kale, raw kale, mixed boiled pig kidney with raw kale and CdCl 2 after in vitro digestion. Then cellular Cd uptake from the digests and reference CdCl 2 solution was measured by atomic absorption spectrometry. Results: Cd bioavailability from animal-based foods was higher than that from vegetable-based foods. In addition, raw kale exhibited an inhibitory effect on Cd bioavailability when mixed with boiled pig kidney. However, Cd in kale was increasingly absorbed after boiling. Conclusion: Cd binding to different molecular species, other food components in vegetable and animal-based foods, food combination, as well as cooking processes influenced the uptake of dietary Cd. A relative bioavailability factor accounted for the food matrix might be necessary for exposure assessment and consequently for estimation and prevention of the risk of dietary Cd.Mahidol UniversityMedicineArticleSCOPUS