Wongkummool W.Tong-ngam P.Munkongdee T.Tangprasittipap A.Paiboonsukwong K.Hongeng S.Fucharoen S.Charoenkwan P.Tubsuwan A.Mahidol University2023-06-182023-06-182022-12-01Stem Cell Research Vol.65 (2022)18735061https://repository.li.mahidol.ac.th/handle/20.500.14594/83509Hemoglobin Constant Spring (HbCS) is unstable hemoglobin resulting from a nucleotide substitution at the termination codon of the HBA2 gene (c.427 T > C). The homozygous state for HbCS is non-transfusion dependent in adults. Nevertheless, severe anemia is often observed in fetuses. Here, human induced pluripotent stem cell line MUi034-A was generated from peripheral blood CD34+ hematopoietic stem/progenitor cells (HSPCs) derived from a 14-year-old female with homozygous HbCS who had a history of severe anemia and hydrops during fetal period. The MUi034-A cell line represented embryonic-like characteristics as they expressed specific pluripotency markers, differentiated into the three germ layers, and retained normal karyotyping.Biochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1016/j.scr.2022.1029792-s2.0-851436449871876775336427475