Dae Hun KimJi Young ChoiHae Won KimSo Hyun KimDoo Ryeon ChungKyong Ran PeckVisanu ThamlikitkulThomas Man Kit SoRohani M.D. YasinPo Ren HsuehCelia C. CarlosLi Yang HsuLatre BuntaranM. K. LalithaJae Hoon SongKwan Soo KoSungKyunKwan University, School of MedicineAsia Pacific Foundation for Infectious Diseases (APFID)Mahidol UniversityPrincess Margaret Hospital Hong KongInstitute for Medical Research Kuala LumpurNational Taiwan University HospitalGokilaNational University Hospital, SingaporeHarapan Kita Cardiovascular HospitalDepartment of MicrobiologySureCare Medical Centre2018-10-192018-10-192013-11-01Antimicrobial Agents and Chemotherapy. Vol.57, No.11 (2013), 5239-524610986596006648042-s2.0-84885921183https://repository.li.mahidol.ac.th/handle/20.500.14594/32102In this surveillance study, we identified the genotypes, carbapenem resistance determinants, and structural variations of AbaRtype resistance islands among carbapenem-resistant Acinetobacter baumannii (CRAB) isolates from nine Asian locales. Clonal complex 92 (CC92), corresponding to global clone 2 (GC2), was the most prevalent in most Asian locales (83/108 isolates; 76.9%). CC108, or GC1, was a predominant clone in India. OXA-23 oxacillinase was detected in CRAB isolates from most Asian locales except Taiwan. blaOXA-24 was found in CRAB isolates from Taiwan. AbaR4-type resistance islands, which were divided into six subtypes, were identified in most CRAB isolates investigated. Five isolates from India, Malaysia, Singapore, and Hong Kong contained AbaR3-type resistance islands. Of these, three isolates harbored both AbaR3- and AbaR4-type resistance islands simultaneously. In this study, GC2 was revealed as a prevalent clone in most Asian locales, with the AbaR4-type resistance island predominant, with diverse variants. The significance of this study lies in identifying the spread of global clones of carbapenemresistant A. baumannii in Asia. Copyright © 2013, American Society for Microbiology. All Rights Reserved.Mahidol UniversityMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1128/AAC.00633-13