A. BunyaratvejS. SahaphongN. BhamarapravatiP. WasiMahidol University2018-10-122018-10-121983-01-01Acta Haematologica. Vol.69, No.5 (1983), 314-318000157922-s2.0-0020698265https://repository.li.mahidol.ac.th/handle/20.500.14594/30534Electron microscopic examination of intraerythrocytic inclusion bodies induced by methylene blue was carried out in 7 non-splenectomized patients with haemoglobin (Hb) H disease. In classical Hb H disease with the genotype of α-thalassaemia 1/α-thalassaemia 2 the inclusion bodies were mostly membrane-associated. In contrast, in Hb H disease of α-thalassaemia 1/Hb Constant Spring genotype the majority of inclusion bodies were in a floating stage. Possible mechanisms for the unexpected difference are discussed.Mahidol UniversityMedicineArticleSCOPUS10.1159/000206975