Supakrit AuiwattanakulKaweesak ChittawatanaratOnuma ChaiwatSunthiti MorakulSuneerat KongsayreepongWinai UngpinitpongSurakrant YutthakasemsuntSupawan BuranapinSuranaree University of TechnologySurin HospitalFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversityKhon Kaen Regional HospitalFaculty of Medicine, Siriraj Hospital, Mahidol UniversityChiang Mai University2020-01-272020-01-272019-02-01Nutrition. Vol.58, (2019), 94-9918731244089990072-s2.0-85055903857https://repository.li.mahidol.ac.th/handle/20.500.14594/51924© 2018 Elsevier Ltd Objectives: The aim of this study was to demonstrate the role of nutrition factors on a 28-d mortality outcome and sepsis occurrence in surgical intensive care unit. Methods: The data was extracted from a THAI-SICU study that prospectively recruited participants (≥18 y of age) from three Thai surgical intensive care units (SICUs) of university-based hospitals. The demographic data and nutrition factors at SICU admission included energy delivery deficit, weight loss severity, route of energy delivery, and albumin and nutrition risk screening (NRS-2002). The outcomes were 28-d hospital mortality and sepsis occurrence. The statistical analysis was performed using Cox regression. Results: The study included 1503 eligible patients with a predominantly male population. The 28-d mortality and sepsis occurrences were 211 (14%) and 452 (30%), respectively. Regarding multivariable analysis, for mortality outcome, the protective effects of nutrition variables were higher body mass index (BMI; hazard ratio [HR], 0.82; 95% confidence interval [CI], 0.68–0.99; P = 0.039), tube feeding (HR, 0.46; 95% CI, 0.26–0.83; P = 0.010), and a combination of enteral and parenteral nutrition (HR, 0.24; 95% CI, 0.07–0.77; P = 0.016). The harmful effects were severe weight loss (HR, 1.61; 95% CI, 1.16–2.22; P = 0.004), albumin ≤2.5 (HR, 2.15; 95% CI, 1.20–3.84; P = 0.010), and at risk according to NRS-2002 (HR, 1.34; 95% CI, 0.98–1.85; P = 0.071). For the sepsis occurrence, only tube feeding had a protective effect (HR, 0.58; 95% CI, 0.39–0.88; P = 0.009), and only albumin ≤2.5 had a harmful effect (HR, 1.71; 95% CI, 1.20–2.45; P = 0.003). Conclusion: Nutrition factors affecting the mortality or sepsis occurrence in this study were BMI, enteral feeding or combination with parenteral nutrition, severe weight loss, preadmission albumin ≤2.5, and at risk according to NRS-2002.Mahidol UniversityMedicineArticleSCOPUS10.1016/j.nut.2018.06.021