Friederike I. NollmannAntje K. HeinrichAlexander O. BrachmannChristophe MorisseauKrishnendu MukherjeeÁngel M. Casanova-TorresFrederic StroblDavid KleinhansSebastian KinskiKatharina SchultzMichael L. BeetonMarcel KaiserYa Yun ChuLong Phan KeAunchalee ThanwisaiKenan A.J. BozhüyükNarisara ChantratitaFriedrich GötzNick R. WaterfieldAndreas VilcinskasErnst H.K. StelzerHeidi Goodrich-BlairBruce D. HammockHelge B. BodeGoethe-Universitat Frankfurt am MainUniversity of California, DavisFraunhofer Institute for Molecular Biology and Applied Ecology IMEUniversity of Wisconsin MadisonCardiff Metropolitan UniversityUniversitat BaselUniversitat TubingenVietnamese Academy of Science and TechnologyNaresuan UniversityMahidol UniversityWarwick Medical School2018-11-232018-11-232015-03-23ChemBioChem. Vol.16, No.5 (2015), 766-77114397633143942272-s2.0-84924856546https://repository.li.mahidol.ac.th/handle/123456789/35485© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Simple urea compounds ("phurealipids") have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryArticleSCOPUS10.1002/cbic.201402650