Diego A. ReyAaron D. StricklandDickson KiruiNuttawee NiamsiriCarl A. BattCornell UniversityMahidol University2018-09-242018-09-242010-07-28ACS Applied Materials and Interfaces. Vol.2, No.7 (2010), 1804-181019448252194482442-s2.0-77956631364https://repository.li.mahidol.ac.th/handle/20.500.14594/29302Polyhydroxyalkanoate (PHA) synthase attached to gold nanoparticles (AuNP) produce poly(3-hydroxybutyrate) (PHB) upon the addition of 3-hydroxybutyrate- CoA, and then coalesce to form micrometer-sized AuNP-coated PHB granules. These AuNP-coated PHB granules are potential theranostic agents that have enhanced imaging capabilities and are capable of heating upon near-infrared laser irradiation. The AuNP-coated PHB exhibited 11-fold enhancement in surface-enhanced Raman scattering over particles prior polymerization. Stained AuNP-coated PHB exhibited a 6-fold enhancement in fluorescence intensity as well as a 1.3-fold decrease in photobleaching rate compared to PHB granules alone. The granules were also shown to emit heat when illuminated at 808 nm with a 3.9-fold increase in heating rate compared to particles alone. © 2010 American Chemical Society.Mahidol UniversityMaterials ScienceArticleSCOPUS10.1021/am100306m