Patcharee ArsakhantUthaiwan SirionArthit ChairoungduaKanoknetr SuksenPawinee PiyachaturawatApichart SuksamrarnRungnapha SaeengRamkhamhaeng UniversityMahidol UniversityBurapha University2020-06-022020-06-022020-07-15Bioorganic and Medicinal Chemistry Letters. Vol.30, No.14 (2020)146434050960894X2-s2.0-85084649114https://repository.li.mahidol.ac.th/handle/20.500.14594/56106© 2020 Elsevier Ltd A series of 21 new analogues of C-12 dithiocarbamate andrographolide was designed and synthesized from natural andrographolide isolated from a common Thai plant, Andrographis paniculata. The reaction used to manipulate the andrographolide scaffold was conducted in one pot under mild reaction conditions. This avoided toxic catalysts and gave nearly quantitative yields of new analogues, generally without by-products and can be easily scaled -up for industrial processing. All new analogues were evaluated against nine cancer cell lines, some analogues exhibited greater selective cytotoxic activity to MCF-7 cancer cell than that of the parent andrographolide and cancer drugs.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/j.bmcl.2020.127263