Sirirat KumarnNitirat ChimnoiSomsak RuchirawatMahidol UniversityChulabhorn Research InstituteSouth Carolina Commission on Higher Education2018-10-192018-10-192013-01-01Organic and Biomolecular Chemistry. Vol.11, No.44 (2013), 7760-7767147705202-s2.0-84886408136https://repository.li.mahidol.ac.th/handle/20.500.14594/31411A solid-phase total synthesis of integerrimide A (1) is reported. This work employs a safety-catch linker which enables head-to-tail cyclisation of the required linear peptide 6 as a method of cleaving the peptide from the solid support, and highlights a new tandem approach to direct macrocyclisation. It provides access to useful quantities of 1 in 16 steps and 19% overall yield, based on the manufacturer's stated resin substitution from commercially available materials, and also verifies the absolute stereochemistry of the natural product. © The Royal Society of Chemistry 2013.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryArticleSCOPUS10.1039/c3ob41447g